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M94A2717.TXT
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1994-10-25
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Document 2717
DOCN M94A2717
TI Cross-reactivity of particle agglutination test for antibody to HIV-2.
DT 9412
AU Handa N; Maeda Y; Kato M; Tokyo Metropolitan Komagome Hospital, Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):240 (abstract no. PB0390). Unique
Identifier : AIDSLINE ICA10/94369858
AB OBJECTIVE: We purposed to examine the prevalence of HIV-2 infection in
the persons with HIV-1 infection in our hospital and to test
cross-reactivity of particle agglutination (PA) test for antibody to
HIV-2. METHODS: PA test for antibody to HIV-2 was performed on 253 serum
samples from persons with HIV-1 infection. These samples had been
determined reactive by HIV-1 PA test and HIV-1 Western blot. The anti
HIV antibody titer was expressed as the reciprocal of the highest
dilution of serum giving a positive reaction. Serum samples repeatedly
reactive by PA test were tested by Lav blot 1,2 and Pepti-lav 1,2. The
profiles were interpreted by WHO criteria. RESULTS: Of the 253 samples
tested, 196 were reactive at 1:32 only by HIV-1 PA test, 57 were
reactive by both HIV-1 and HIV-2 PA test at 1:32 and 1:64 respectively.
The highest titer of anti HIV-1 antibody was 10,000,000, and that of
anti HIV-2 antibody was 64,000. The titer ratios (HIV-1/HIV-2) ranged
from 10 to 39,063. Of the 57 specimens with positive HIV-1 and HIV-2 PA
results, none was reactive by HIV-2 Western blot. DISCUSSION AND
CONCLUSIONS: A total of 253 persons were confirmed as HIV-1 infected. No
person with HIV-2 infection or double infection was detected.
Cross-reactivity ratio was 22.5% (57/253).
DE *Agglutination Tests *AIDS Serodiagnosis Blotting, Western Cross
Reactions/*IMMUNOLOGY Human HIV Antibodies/*BLOOD HIV
Seropositivity/*DIAGNOSIS/IMMUNOLOGY HIV Seroprevalence
HIV-1/*IMMUNOLOGY HIV-2/*IMMUNOLOGY Predictive Value of Tests MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).